Cranalon™, 14 pcs
Exclusive Cranalon™ formula contains Fibersol 2™ - a patented ingredient, soluble dietary fiber; the potent antioxidant Phenalgin™ (phlorotannin extract, produced using a proprietary technology), and Aloe Vera gel concentrate (200:1).
The product has been manufactured using high quality pure raw materials and the technology that ensures all their beneficial properties intact, in strict compliance with GMP and TÜV regulations.
Cranalon™ is an exclusive Santegra®’s product, it is a multivitamin formula with cleansing and energizing properties in a glass of refreshing beverage. The name Cranalon™ is derived from the names of two main ingredients, popular in folk medicine – cranberry and aloe.
Aloe Vera is often called the ’miracle plant’ or the ’natural healer’, and is used all over the world for more than 5000 years.
It was used in ancient Egypt (mentioned in Egyptian papyrus dated 1550 BC).
Ancient Greeks admired its unique properties, but the cost of aloe was very high. Legend suggests that Alexander the Great conquered the island of Socotra in the Indian Ocean to secure supplies of Aloe to treat the battle wounds of his soldiers.
Nowadays aloe is widely used for prevention of many diseases and for maintaining overall health. Aloe improves digestion, regulates the acidity of gastric juices, improves bowel movements, has mild laxative effect, cleanses the body, and helps in disease prevention. (1)
Aloe helps in vitamin and mineral absorption, has anti-inflammatory, antiviral properties, supports the immune system, and helps relieve allergy symptoms. Aloe speeds wound healing, improves skin condition, its softness and elasticity. (2)
Cranberry is used both in folk medicine and in cuisine for centuries.
A study carried out in 2000 by Wang and Jiao revealed that cranberry juice is an effective scavenger of free radicals; therefore, the plant has antioxidant properties. Cranberry is also rich in flavonoids and vitamin C. Clinical trials showed that cranberry helps prevent urinary tract infections. (5,6)
It is well known that healthy diet includes nutrients, which are divided into 5 groups: proteins, carbohydrates, fats, vitamins and minerals. But researches discovered that there is one more group of nutrients, vitally essential for the human health – dietary fiber. Dietary fiber promotes the cleansing of the body, helps regulate sugar and cholesterol levels, and lowers the risk of developing different diseases.
Unfortunately, only few of us have adequate consumption of dietary fiber.
Cranalon™ contains Fibersol 2™ - a soluble dietary fiber that is produced from cornstarch by pyrolysis and subsequent enzymatic treatment. Fibersol 2™ is classified as "resistant maltodextrin".
Fibersol 2™ helps to maintain normal levels of triglycerides and cholesterol, positively influences blood glucose levels, promotes the growth of “friendly” intestinal bacteria. It also helps maintain healthy intestinal regularity, potentially reducing the incidence of various diseases.
Phenalgin™ is produced from brown algae (Cystoseira canariensis) using a proprietary technology, which guarantees the absence of pesticides, heavy metals, etc. Phenalgin™ contains highly active polyphenols called phlorotannins, which are shown to have powerful anti-oxidant activity. Phenalgin™ is rich in B group vitamins.
Red algae (Dunaliella Salina) are the unique plants from Australia, which are packed with health-promoting nutrients. The unmatched carotenoid content of Dunaliella Salina provides many health benefits; it is also a potent antioxidant.
Malic acid is a natural acid derived from apples that plays an essential role in the production of energy.
Mix one packet with a glass (200 ml) of cold water, stir thoroughly, and take as a dietary supplements 1-2 times daily before a meal.
Feeling sluggish? Having skin problems, headache, depressed immunity, allergy-like symptoms, constipation, skin rashes, mood changes or digestiion problems? It might be time for a body cleanse.
Toxins are naturally produced through the body’s everyday functions. Additionally, we all are exposed to environmental toxins on a daily basis in the form of air and water pollution, food additives, caffeine, cigarette smoke, pesticides, and a number of other environmental chemicals. Studies suggest that the cumulative effect of such toxins pose a great health risk.
If you are in good health, you generally can handle exposure to a normal level of everyday toxins; your body is built to handle it. The liver, lungs, kidneys, and bowels constantly work together to detoxify every cell, organ and system in your body. That is why it is essential to keep these organs in top shape.
Simple lifestyle changes can help with the ongoing detoxification of your body. Work to reduce stress and emphasize positive emotions. Get plenty of sleep. In addition, get regular exercise - it is a great way to help your body release toxins. Walking, jogging, or practicing yoga all can help you in your detoxification efforts.
Basic detoxification usually begins with a change in diet. Drinking plenty of water each day is a good start, as is eating more fruits, vegetables, whole grains, legumes, nuts and seeds that contain plenty of fiber.
Dietary fiber became a household word back in 1970s when Dr. Denis Burkitt, a man nicknamed the Fiber Man, and his colleagues made "the fiber hypothesis" that states that health fiber can prevent certain diseases. Through their work in Africa, they discovered that diseases that were common in the Western cultures were not common there. These included heart attacks and high blood pressure, obesity and diabetes, constipation. The primary dietary difference was the high intake of fiber and low intake of refined carbohydrates in the African population.
Unfortunately, most of the population of the developed countries does not get enough soluble fiber or insoluble fiber in their diets. In fact, it is estimated that Americans eat 12 g of dietary fiber on average per day, a far cry from the 20 to 30 g per day recommended by the National Cancer Institute (NCI).
Fibersol 2™ is soluble dietary fiber produced by the pyrolysis and controlled enzymatic hydrolysis of cornstarch.
Fibersol 2™ is fermented slowly, thus producing less acid and gas than most soluble dietary fibers.
The left picture shows a regular absorption pattern of sugar/starch. The most part of it is absorbed in the stomach. The right picture shows the process of absorption of sugar/starch with Fibersol 2™. Only a small part is digested in the stomach, most of it reaches large intestine and is used as a food for beneficial bacteria, normalizes the intestine microflora, increases the fecal volume.
Fibersol 2™ slows absorption that is beneficial for the blood glucose level and regulates the insulin production (pic.1). It is shown that blood glucose level rise after Fibersol 2™ intake is lower (right diagram).
Ohkuma & Wakabayashi in Advanced Dietary Fiber Technology, 2001, described over ten years of nutritional feeding studies in animals and humans worldwide.
- helps maintain healthy blood glucose levels and subsequent insulin response.
Studies indicate that Fibersol 2™ can effectively reduce serum blood glucose level, potentially allowing formulation to be used in foods for diabetics, weight control, and managing serum glucose before, during, and after exercise.
- helps maintain healthy levels of blood triglycerides and serum cholesterol.
Fibersol 2™ significantly reduces levels of blood triglycerides and serum cholesterol. Additionally, Fibersol 2™ effectively retains levels of HDL (good) cholesterol. All this potentially impacts the incidence of coronary heart disease and related diseases.
Fibersol 2™ lowers serum cholesterol levels and triglyceride levels but does not reduce HDL-cholesterol levels.
- helps maintain healthy intestinal regularity.
By adding stool volume, moisture, and reducing transit time, Fibersol 2™ helps maintain good colon health, potentially reducing the incidence of various types of colon diseases. In addition, Fibersol 2™ has been shown to prevent atrophy of the lining of the large intestine and does not create excess gas associated with some soluble dietary fibers. .
- helps promote the growth of beneficial bacteria in the colon.
As a water-soluble fiber, Fibersol 2™ can effectively promote the growth of a variety of beneficial bacteria (naturally occurring or ingested as probiotics) in the colon. In promoting the growth of beneficial bacteria, Fibersol 2™ indirectly reduces the presence of undesirable bacterial species. )
Clinical trial (subjects: 6 males and 14 females prone to constipation) showed that after Fibersol 2™ intake the fecal frequencies increased almost twice. (4)
Fecal frequency study over a 5 day-period:
2.6 times before Fibersol 2™ intake.
4.0 times after Fibersol 2™ intake (3.75 grams/day).
More than 150 clinical trials were conducted with the purpose to determine the influence of dietary fibers on the condition of cardio-vascular system. The increased cholesterol level is one of the major risk factor of coronary heart diseases. The findings demonstrated that soluble fiber reduces the risk of heart disease by lowering cholesterol and LDL. Soluble fibers decrease the bile absorption process. Bile, which contains cholesterol, is necessary for the digestion of fat. It is secreted into the intestine in response to food intake and most of it is reabsorbed after digestion is completed, when soluble fiber is present not as much bile is reabsorbed.
The Nurses’ Health Study, a large, prospective cohort study of US women followed up for 10 years from 1984. Dietary data were collected in 1984, 1986, and 1990, using a validated semiquantitative food frequency questionnaire.
A total of 68782 women aged 37 to 64 years without previously diagnosed angina, myocardial infarction (MI), stroke, cancer, hypercholesterolemia, or diabetes at baseline.
Response rate averaged 80% to 90% during the 10-year follow-up. Were documented 591 major CHD events (429 nonfatal MIs and 162 CHD deaths). The age-adjusted relative risk (RR) for major CHD events was 0.53 (95% confidence interval [CI], 0.40-0.69) for women in the highest quintile of total dietary fiber intake (median, 22.9 g/d) compared with women in the lowest quintile (median, 11.5 g/d). After controlling for age, cardiovascular risk factors, dietary factors, and multivitamin supplement use, the RR was 0.77 (95% CI, 0.57-1.04).
For a 10-g/d increase in total fiber intake (the difference between the lowest and highest quintiles), the multivariate RR of total CHD events was 0.81 (95% CI, 0.66-0.99). Among different sources of dietary fiber (eg, cereal, vegetables, fruit), only cereal fiber was strongly associated with a reduced risk of CHD (multivariate RR, 0.63; 95% CI, 0.49-0.81 for each 5-g/d increase in cereal fiber).
CONCLUSIONS: Our findings in women support the hypothesis that higher fiber intake, particularly from cereal sources, reduces the risk of CHD. (7)
The research conducted in Netherlands showed that men using insufficient amount of dietary fibers are four times more susceptible to fatal results of CVD. The daily dietary fiber intake should be no less than 37 mg per day.
The adequate fiber diets add material to the waste stream, which would normalize the pathological processes: increase or decrease intestinal transit time. The British scientist D. Burkitt found the direct relation between the transit time of fecal mass and the ratio of vegetable fibers in the daily diet.
Burkitt et al, in compared various population groups and found that those on high fiber diets produced stools of 150- 980 grams/day, with transit times of 19-68 hours. Those on low fiber produced stools of 39-195 grams/day with transit times of 28-144 hours. (8)
Centre for Gastroenterology, Institute of Cellular and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK.
The herbal preparation, aloe vera, has been claimed to have anti-inflammatory effects and, despite a lack of evidence of its therapeutic efficacy, is widely used by patients with inflammatory bowel disease. AIM: To perform a double-blind, randomized, placebo-controlled trial of the efficacy and safety of aloe vera gel for the treatment of mildly to moderately active ulcerative colitis. METHODS: Forty-four evaluable hospital out-patients were randomly given oral aloe vera gel or placebo, 100 mL twice daily for 4 weeks, in a 2 : 1 ratio.
RESULTS: Clinical remission, improvement and response occurred in nine (30%), 11 (37%) and 14 (47%), respectively, of 30 patients given aloe vera, compared with one (7%) [P = 0.09; odds ratio, 5.6 (0.6-49)], one (7%) [P = 0.06; odds ratio, 7.5 (0.9-66)] and two (14%) [P < 0.05; odds ratio, 5.3 (1.0-27)], respectively, of 14 patients taking placebo. The Simple Clinical Colitis Activity Index and histological scores decreased significantly during treatment with aloe vera (P = 0.01 and P = 0.03, respectively), but not with placebo. Adverse events were minor and similar in both groups of patients. (9)
CONCLUSION: Oral aloe vera taken for 4 weeks produced a clinical response more often than placebo; it also reduced the histological disease activity and appeared to be safe. Further evaluation of the therapeutic potential of aloe vera gel in inflammatory bowel disease is needed.
Faculty of Allied Health, Medical Laboratory Sciences, Kuwait University, P.O. Box 31470, Sulaibikhat 90805, Kuwait. firstname.lastname@example.org
The present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of Aloe barbadensis Miller. A simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely TNF-alpha and IL-1 beta, from peripheral blood leukocytes stimulated with Shigella flexneri or LPS. This report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health drink from the same source. Comparison was made with a human monocytic cell-line (THP-1 cells) and a similar trend in responses was demonstrated. (10)
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
Thirty one healthy male medical students between 18 and 23 years of age were enrolled in the clinical trial. Subjects ingested 100 g of fresh aloe gel twice a day for seven consecutive days. The 24-hr urine was collected one day prior to taking the gel (Day 0), Days 2 and 5 of consumption, and Day 8 (one day after completion).
CONCLUSION: Fresh Aloe vera gel (100 g) contains 96.3 mg of citrate and 158.9 mg of tartrate. This is mid-range for Thai fruits. Changes in chemical compositions of urine after aloe consumption shows its potential for preventing kidney stone formation among adults. (11)
1. Atherton P. Aloe vera: magic or medicine? Nurs Stand. 1998 Jul 1-7;12(41):49-52, 54.
2. Grindlay D, Reynolds T. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J Ethnopharmacol. 1986 Jun;16(2-3):117-51.
3. Tokunaga K and Matsuoka A, "Effects of a [FOSHU] which contains indigestible dextrin as an effective ingredient on glucose and lipid metabolism," J Japanese Diabetes Society, 42:61-65, 1999.
4. Satouchi M et al, "Effects of indigestible dextrin on bowel movements," Japanese J Nutr, 51:31-37, 1993.
5. Walker EB, Barney DP, Mickelsen JN, et al. Cranberry concentrate: UTI prophylaxis. J Family Pract 1997;45:167-8 [letter].
6. Avorn J, Monane M, Gurwitz JH, et al. Reduction of bacteriuria and pyruria after ingestion of cranberry juice. JAMA 1994;271:751-4.
7. Wolk A, Manson JE, Stampfer MJ, Colditz GA, Hu FB, Speizer FE, Hennekens CH, Willett WC. Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. JAMA. 1999 Jun 2;281(21):1998-2004.
8. Burkitt D., Wake r A., Painter N. Effect of dietary fiber on stools and transit times and its role in the causation of disease//Lancet.—1972.—Vol. 2.—P. 1408—1412.
9. Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, De Silva A, Jewell DP, Rampton DS. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther. 2004 Apr 1;19(7):739-47
10. Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA. The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods. 2007 Aug;42(4):388-93
11. Kirdpon S, Kirdpon W, Airarat W, Trevanich A, Nanakorn S. Effect of aloe (Aloe vera Linn.) on healthy adult volunteers: changes in urinary composition. J Med Assoc Thai. 2006 Aug;89 Suppl 2:S9-14.