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Una de Gato GP (30) | 11362

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Una de Gato GP contains the standardized extract (4:1) of Uncaria tomentosa bark (3% total oxindole alkaloids) that guarantees its efficacy. The content of one capsule (350 mg) is equivalent to 1400 mg of crude herb.
The product has been manufactured using high quality pure raw materials and the technology that ensures all their beneficial properties intact, in strict compliance with GMP and TÜV regulations.

Una de Gato GP (30)

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Exclusive Santegra®’s product Una de Gato GP contains standardized Uncaria tomentosa bark extract (3% total oxindole alkaloids).

Uncaria tomentosa, commonly known as Una de gato or cat’s claw grows wild in the Amazon region of Peru and neighboring countries between 400 and 800 meters above sea level. It can reach several inches in diameter and 1,000 feet in height. Cat’s claw gets its name from the sharp thorns on its stem, resembling the claws of a cat.

Cat’s Claw has been used by the Native Americans of Peru for 2000 years and to this very day it is thought to be sacred, the “Miracle cure for all diseases”.

Cat’s claw has a long history of use by native peoples as a folk medicine to treat intestinal complaints, asthma, wounds, ulcers, tumors, arthritis, inflammations, diabetes, menstrual cycle irregularities, fevers, dysentery, and rheumatism and even was used as a contraceptive. Moreover, it was noticed that the native population almost does not suffer from tumors.

After these claims drew the attention of scientists in Europe and the USA, tests began to demonstrate that active components in cat’s claw boost the activity of the immune system, reduce inflammation, and scavenge damaging particles known as free radicals. Cat’s Claw may also offer antibacterial, antiviral, antimutagenic, and anti-tumor properties.

The inner bark of cat’s claw is a rich source of valuable biologically active constituents. Research on Cat’s Claw began in the early 1970’s. In 1989 the plant’s main active ingredients oxindole alkaloids were isolated and tested.

Oxindole alkaloids have been proven to be effective immunostimulants. Some of them display an ability to inhibit platelet aggregation and thrombosis, and may be useful in the prevention of stroke and reducing the risk of heart attack.

As well as these alkaloids researchers have discovered other beneficial phytochemicals inherent in the plant, including proanthocyanidins, polyphenols, triterpines, and the plant sterols: beta-sitosterol, stigmasterol and campesterol. That might explain the antioxidant, anti-microbial, anti-tumor and anti- inflammatory properties attributed to this plant.

Uncaria tomentosa has a profound positive influence on the body’s defense system. It helps to activate macrophages, lymphocytes and leukocytes, normalizes immunoglobulin level, and modulates immune reactions. Quinovic acid glycoside, found in Uncaria tomentosa is one of the most active anti-inflammatory principles to be uncovered.

Many of the testimonials to the healing power of Cat’s Claw describe wonderful results in the treatment of parasitic infections and chronic digestive disturbances. Una de Gato cleanses and detoxifies the body. Due to its antacidic action and ability to improve the cicatrisation process, Uncaria tomentosa is beneficial for people suffering from increased gastric acidity, stomach and duodenal ulcers, and chronic gastritis. Scientists observed that active ingredients in Uncaria tomentosa inhibited the growth of some tumor cells. Una de Gato can be used in tumor prevention.

The unique Santegra®’s product Una de Gato GP contains the standardized extract (4:1) of Uncaria tomentosa bark (3% total oxindole alkaloids) that greatly increases its efficacy.  The content of one capsule is equivalent to 1400 mg of crude herb.

El Dorado secret is discovered by modern science and now it is available to you.

Name Una de Gato GP (30)
Product Line Formata

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Usage

Take 1 capsule a day with a meal and a glass of water.


Contraindication

Individual intolerance. Do not use this product if pregnant or nursing.

Per one capsule:

Cat’s Claw (Uncaria tomentosa (Willd.) DC) (4:1 bark extract standardized to 3% total oxindole alkaloids; equivalent to 1400 mg of crude herb) - 350 mg.

OBJECTIVE: To evaluate safety and clinical efficacy of a plant extract from the pentacyclic chemotype of Uncaria tomentosa (UT) in patients with active rheumatoid arthritis (RA). 
METHODS: Forty patients undergoing sulfasalazine or hydroxychloroquine treatment were enrolled in a randomized 52 week, 2 phase study. During the first phase (24 weeks, double blind, placebo controlled), patients were treated with UT extract or placebo. In the second phase (28 weeks) all patients received the plant extract. 
RESULTS: Twenty-four weeks of treatment with the UT extract resulted in a reduction of the number of painful joints compared to placebo (by 53.2% vs 24.1%; p = 0.044). Patients receiving the UT extract only during the second phase experienced a reduction in the number of painful (p = 0.003) and swollen joints (p = 0.007) and the Ritchie Index (p = 0.004) compared to the values after 24 weeks of placebo. Only minor side effects were observed.

CONCLUSION: Cat’s claw is an effective treatment for osteoarthritis. The species, U guianensis and U tomentosa are equiactive. They are effective antioxidants, but their anti-inflammatory properties may result from their ability to inhibit TNFalpha and to a lesser extent PGE2 production. (5)

BACKGROUND: Uncaria tomentosa is a vine commonly known as cat’s claw or ’uña de gato’ (UG) and is used in traditional Peruvian medicine for the treatment of a wide range of health problems, particularly digestive complaints and arthritis.

PURPOSE: The aim of this study was to determine the proposed anti-inflammatory properties of cat’s claw. Specifically: (i) does a bark extract of cat’s claw protect against oxidant-induced stress in vitro, and (ii) to determine if UG modifies transcriptionally regulated events.

METHODS: Cell death was determined in two cell lines, RAW 264.7 and HT29 in response to peroxynitrite (PN, 300 microM). Gene expression of inducible nitric oxide synthase (iNOS) in HT29 cells, direct effects on nitric oxide and peroxynitrite levels, and activation of NF-kappaB in RAW 264.7 cells as influenced by UG were assessed. Chronic intestinal inflammation was induced in rats with indomethacin (7.5 mg/kg), with UG administered orally in the drinking water (5 mg/mL).

RESULTS: The administration of UG (100 microg/mL) attenuated (P < 0.05) peroxynitrite-induced apoptosis in HT29 (epithelial) and RAW 264.7 cells (macrophage). Cat’s claw inhibited lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappaB. Cat’s claw markedly attenuated indomethacin-enteritis as evident by reduced myeloperoxidase activity, morphometric damage and liver metallothionein expression.

CONCLUSIONS: Cat’s claw protects cells against oxidative stress and negated the activation of NF-kappaB. These studies provide a mechanistic evidence for the widely held belief that cat’s claw is an effective anti-inflammatory agent. (6)

Uncaria tomentosa inner bark extract is a popular plant remedy used in folk medicine to treat tumor and inflammatory processes. In this study, the anti-tumoral effects of its pentacyclic alkaloid mitraphylline were investigated. Furthermore, its growth-inhibitory and cytotoxic effects on glioma GAMG and neuroblastoma SKN-BE(2) cell lines were studied using cyclophosphamide and vincristine as controls. A colter counter was used to determine viable cell numbers, followed by application of the tetrazolium compound [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)2-(4-sulfophenyl)-2H-tetrazolium], inner salt, colorimetric method to evaluate cell viability in this cytotoxicity assay. Micromolar concentrations of mitraphylline (from 5 to 40 microM) inhibited the growth of both cell lines. It inhibited the growth of the two cell lines studied in a dose-dependent manner. The IC(50) values were 12.3 microM (30h) for SKN-BE(2) and 20 microM (48 h) for GAMG, respectively. This action suggests that mitraphylline is a new and promising agent in the treatment of human neuroblastoma and glioma. (7)

Uncaria tomentosa, also known as "Uña de gato", is a Rubiaceae species widely used in South-American folk medicine for the treatment of cancer, arthritis, gastritis and epidemic diseases. Extracts of the plant have been shown to possess cytostatic and anti-inflammatory activity as well as mutagenic and antimutagenic properties. However, to date no studies have been carried out to verify the direct antitumor activity of the extracts. The present study investigates the effects of some extracts and their chromatographic fractions from the bark of U. tomentosa on the growth of a human breast cancer cell line (MCF7). Our data indicated that, in addition to the antimutagenic activity, U. tomentosa extracts and fractions exert a direct antiproliferative activity on MCF7. The bioassay-directed fractionation from barks and leaves resulted in the isolation of two active fractions, which displayed an IC50 of 10 mg/ml and 20 mg/ml, respectively and an antiproliferative effect, with about 90% of inhibition at a concentration of 100 mg/ml. (8)

Female W/Fu rats were gavaged daily with a water-soluble extract (C-MED-100) of Uncaria tomentosa supplied commercially by CampaMed at the doses of 0, 5, 10, 20, 40 and 80 mg/kg for 8 consecutive weeks. Phytohemagglutinin (PHA) stimulated lymphocyte proliferation was significantly increased in splenocytes of rats treated at the doses of 40 and 80 mg/kg. White blood cells (WBC) from the C-MED-100 treatment groups of 40 and 80 mg/kg for 8 weeks or 160 mg/kg for 4 weeks were significantly elevated compared with controls (P < 0.05). In a human volunteer study, C-MED-100 was given daily at 5 mg/kg for 6 consecutive weeks to four healthy adult males. No toxicity was observed and again, WBC were significantly elevated (P < 0.05) after supplement. Repair of DNA single strand breaks (SSB) and double strand breaks (DSB) 3 h after 12 Gy whole body irradiation of rats were also significantly improved in C-MED-100 treated animals (P < 0.05). The LD50 and MTD of a single oral dose of C-MED-100 in the rat were observed to be greater than 8 g/kg. Although the rats were treated daily with U. tomentosa extracts at the doses of 10-80 mg/kg for 8 weeks or 160 mg/kg for 4 weeks, no acute or chronic toxicity signs were observed symptomatically. In addition, no body weight, food consumption, organ weight and kidney, liver, spleen, and heart pathological changes were found to be associated with C-MED-100 treatment. (9)

The Uncaria tomentosa water extracts (C-Med-100) have been shown to enhance DNA repair, mitogenic response and leukocyte recovery after chemotherapy-induced DNA damage in vivo. In this study, the effect of C-Med-100 supplement was evaluated in a human volunteer study. Twelve apparently healthy adults working in the same environment were randomly assigned into 3 groups with age and gender matched. One group was daily supplemented with a 250 mg tablet containing an aqueous extract of Uncaria tomentosa of C-Med-100, and another group with a 350 mg tablet, for 8 consecutive weeks. DNA repair after induction of DNA damage by a standard dose of hydrogen peroxide was measured 3 times before supplement and 3 times after the supplement for the last 3 weeks of the 8 week-supplement period. There were no drug-related toxic responses to C-Med-100 supplement when judged in terms of clinical symptoms, serum clinical chemistry, whole blood analysis and leukocyte differential counts. There was a statistically significant decrease of DNA damage and a concomitant increase of DNA repair in the supplement groups (250 and 350 mg/day) when compared with non-supplemented controls (p < 0.05). There was also an increased tendency of PHA induced lymphocyte proliferation in the treatment groups. Taken together, this trial has confirmed the earlier results obtained in the rat model when estimating DNA repair enhancement by C-Med-100. (10)

Uncaria tomentosa is considered a medicinal plant used over centuries by the peruvian population as an alternative treatment for several diseases. Many microorganisms usually inhabit the human oral cavity and under certain conditions can become etiologic agents of diseases. The aim of the present study was to evaluate the antimicrobial activity of different concentrations of Uncaria tomentosa on different strains of microorganisms isolated from the human oral cavity. Micropulverized Uncaria tomentosa was tested in vitro to determine the minimum inhibitory concentration (MIC) on selected microbial strains. The tested strains were oral clinical isolates of Streptococcus mutans, Staphylococcus spp., Candida albicans, EnterobacteriaceaePseudomonas aeruginosa. The tested concentrations of Uncaria tomentosa ranged from 0.25–5% in Müeller-Hinton agar. Three percent Uncaria tomentosa inhibited 8% of Enterobacteriaceae isolates, 52% of S. mutans and 96% of Staphylococcus spp. The tested concentrations did not present inhibitory effect on P. aeruginosa and C. albicans. It could be concluded that micropulverized Uncaria tomentosa presented antimicrobial activity on Enterobacteriaceae, S. mutans and Staphylococcus spp. isolates. (11)

Viral diseases are an increasing worldwide health concern. As a consequence, the discovery of new natural antiviral agents is important more than ever.

Cat's Claw (Uncaria tomentosa, "Uña de gato") is widely used in South America for treatment of gastritis, arthritis, cancer and inflammatory conditions. Recent literature reports cytostatic, antiproliferative, anti-inflammatory, and anti-mutagenic properties of extracts of the plant. (1)

The use of cat's claw dates back to the Inca civilization. For hundreds of years the Indian tribes have used the inner bark of the tree to prepare a medicinal tea. The native healers use cat's claw to treat asthma, inflammations of the urinary tract, arthritis, rheumatism; to recover from childbirth; as a kidney cleanser; to cure deep wounds; to control inflammation and gastric ulcers; and for cancer.

Una de gato is considered a sacred plant among the Ashaninkas and other indigenous Peruvian Amazonian tribes. For centuries the miraculous healing properties of Cat's Claw were secret, known only to the shamans of the Amazon, who considered that the plant have life-giving properties.

In the early 1970's an Austrian researcher, Klaus Keplinger was introduced to medicinal plants used by the Asháninka Indians of Peru. In those days Uncaria tomentosa was still completely unknown to Western medicine. According to Keplinger, the herb serves as a means of "regulating the physical and spiritual worlds" for these tribal groups. (2)

Keplinger began studying the properties of una de gato and was granted US patents for isolating plant's major active constituents - oxindole alkaloids. In July 1989 was issued U.S. Patent No 4,844,901, and a second patent, No. 4,940,725, was issued in July 1990.

There are six oxindole alkaloids most prevalent in the Cat's Claw bark, known as: isopteropodine, pteropodine, mitraphylline, isomitraphylline, rynchophylline, and isorynchophylline.

The patent documents describe four of these alkaloids (isopteropodine, pteropodine, isomitaphylline, and isorynochophylline) as "proven suitable for unspecified stimulation of the immune system." The most immunologically active alkaloid, according to the patent is lsopteropodine.

Ryncophylline has been shown in laboratory testing to display an ability to inhibit platelet aggregation and thrombosis. This means ryncophylline may be useful in the prevention of stroke and reducing the risk of heart attack by lowering blood pressure, improving circulation, and inhibiting both the formation of plaque on the arterial walls and formation of blood clots in the vessels of the brain, heart and arteries.

Cat’s Claw contains other beneficial constituents including triterpenes, proanthocyanidins, polyphenols, glycosides, and the plant sterols beta-sitosterol, stigmasterol and campesterol.

Results from animal studies and reports of human cases show that cat's claw have anti-inflammatory effects for individuals with osteoarthritis and rheumatoid arthritis, although the mechanism of action is still not absolutely clear.

It is considered that cat's claw is able to enhance overall immunity while increasing stamina and energy in patients who suffer from physical and mental exhaustion due to an overactive or stressful lifestyle. (3)

Una de Gato can be used as a non-specific immunomodulating agent in viral illnesses and cancer, and it may also have potential as an immunomodulating adaptogen in aging. (4)

In one small human study and several animal studies, taking cat's claw may have promoted the repair of DNA damaged by chemotherapy or radiation.

Oxindole alkaloids stimulate the phagocytotic activity of the macrophages.

The oxindole alkaloids increase or reduce the reactivity of the immune system, depending on the initial status. These constituents can thus stimulate a weak immune system and suppress an over-reactive immune system.

Cat's claw is also thought to have anticancer activities and lab results demonstrated growth inhibitory effects on glioma and neuroblastoma cells. (7)

Italian researchers reported in a 2001 in vitro study that cat's claw directly inhibited the growth of a human breast cancer cell line by 90%. (8)

There are 34 species of the genus Uncaria, but Uncaria tomentosa offers the most promise as a therapeutic agent.

Consumers should check the Cat's Claw bottles they buy for "Uncaria tomentosa" and choose from a reputable company.

1. De Martino L, Martinot JL, Franceschelli S, Leone A, Pizza C, De Feo V. Proapoptotic effect of Uncaria tomentosa extracts. J Ethnopharmacol. 2006 Aug 11;107(1):91-4. Epub 2006 Mar 29.
2. Keplinger K, Laus G, Wurm M, et al. Uncaria tomentosa (Willd.) DC. - ethnomedicinal use and new pharmacological, toxicological and botanical results. J Ethnopharmacol 1999;64:23-34.
3. Steinberg, Phillip N., C.N.C., Cat's Claw Update (Uncaria Tomentosa) That Wondrous Herb from the Peruvian Rain Forest, Townsend Letter for Doctors, August/September, 1995.
4. Sheng Y, Bryngelsson C, Pero R. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol 2000;69:115-126.
5. Piscoya J, Rodriguez Z, Bustamante SA, Okuhama NN, Miller MJ, Sandoval M. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001 Sep;50(9):442-8.
6. Sandoval-Chacón M, Thompson JH, Zhang XJ, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet RM, Clark DA, Miller MJ. Antiinflammatory actions of cat's claw: the role of NF-kappaB. Aliment Pharmacol Ther. 1998 Dec;12(12):1279-89.
7. García Prado E, García Gimenez MD, De la Puerta Vázquez R, Espartero Sánchez JL, Sáenz Rodríguez MT. Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine. 2007 Apr;14(4):280-4. Epub 2007 Feb 12.
8. Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C. The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Res. 2001 Jul-Aug;21(4A):2457-61.
9. Sheng Y; Bryngelsson C; Pero R W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa.
Journal of ethnopharmacology 2000;69(2):115-26.
10. Sheng Y, Li L, Holmgren K, Pero RW. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine. 2001 Jul;8(4):275-82.
11. Renzo Alberto Ccahuana-Vasquez; Silvana Soléo Ferreira dos Santos; Cristiane Yumi Koga-Ito; Antonio Olavo Cardoso Jorge. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Braz. oral res. vol.21 no.1 Sгo Paulo Jan./Mar. 2007


 

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