Red Clover Forte (60)
Effective natural formula contains Red clover (Trifolium pratense) flower 4:1 extract, iodine of herbal origin (from Norwegian kelp); active ingredients of Red Clover Forte provide synergetic action.
The product has been manufactured using high quality pure herbs and the technology that ensures all their beneficial properties intact, in strict compliance with GMP and TÜV regulations.
Day after day our body goes through changes. Natural aging process, stress, and regular wear and tear add to the breakdown of bodily functions. Unbalanced diets, bad habits, lack of sleep deteriorate our health. It is time for changes! Chose healthy active life style, proper diet, and use dietary supplements to preserve your organism in the best possible condition, prevent premature aging.
Red Clover Forte is a wonderful herbal formula that helps with overall body cleansing, removes toxins from the cells and blood, improves liver function, and stabilizes immune system and metabolism.
Red Clover Forte’s active ingredients help to detoxify the body by increasing the liver barrier function, laxative, choleretic, and diuretic action. Red Clover Forte possesses antioxidant, anti-bacterial, and anti-inflammatory properties.
Red Clover (Trifolium pratense) is a well known plant. According to the legend, three-leaf Red Clover symbolizes trust, hope, and love. Every year people are looking for a four-leaf plant hoping it would bring luck. Flowers and leaves of Red Clover are used in folk medicine for centuries as a blood cleansing remedy, in skin problems, cough, and for wound healing.
Red Clover is a rich source of minerals: magnesium, copper, calcium, chromium, iron, phosphorus; vitamin A, C, and vitamin B complex; isoflavones, polyphenols, polysaccharides, coumarins, essential oils.
Red Clover stimulates the immune system, improves blood and lymph circulation, has anti-atherosclerotic effect, and contains estrogen-like substances with a positive influence on hormonal balance.
Red Clover is helpful for skin problems, stimulates digestive juices and bile production, has expectorant and spasmolytic action, used for cough and cold.
Red Clover supports nervous system, because of easily digested forms of calcium and magnesium in it. It is very beneficial for cardiovascular system. Some clinical research suggests that this plant can help support blood vessels elasticity, prevents thrombus formation, decrease “bad” cholesterol, and increase “good” cholesterol level.
Sarsaparilla (Smilax officinalis) contains calcium, copper, iron, manganese, potassium, vitamins A, C, vitamin B complex, saponins, glycosidoses, and sitosterols. Sarsaparilla promotes endotoxins removal, diuretic action, urinary tract cleansing, can be used for skin problems.
Licorice (Glycyrrhiza glabra) is a widely known herb that is used in many countries. It is believed to increase viability and energy, postpone aging. Licorice’s active ingredients are glycyrrhizin, flavonol glycosides (liquiritoside), isoflavonoids, sucrose, glucose, asparagine, mineral salts, pectin substances, and etc. that have a positive effect on human health. Licorice has a well pronounced expectorant, smoothing, calming, and mild laxative action, stimulates adrenal cortex to produce its own corticosteroids. Glycyrrhizin increases ciliated epithelium’s activity and mucous membrane’s secretory functions of upper respiratory tract, to ease up expectoration. It has antiulcer and anti-inflammatory action, stimulates interferon production – body’s natural anti-viral defense.
Licorice has a positive effect on gastrointestinal tract, helpful for increased gastric acidity, and demonstrates mild laxative action.
Prickly ash (Zanthoxylum americanum) bark was used traditionally for digestive disorders, for blood purification, skin problems, rheumatism, overall body strengthening. Prickly ash contains alkaloids, tannins, phenols, coumarins, and essential oils.
Prickly ash bark provides toning effect, stimulates blood circulation, improves digestion, and helps with body’s detoxification.
Beet (Beta vulgaris) contains iron, potassium, magnesium, vitamin B1, B2, niacin, B6, B12, C, soluble and insoluble dietary fibers. Beet root improves digestion, and assimilation of many beneficial nutrients. It supports hematosis, strengthens the immune system. One of the ingredients – betaine – stimulates liver functions, helps its regeneration, and as a result of it plays a major role in the detoxification of the body.
Norwegian kelp (Ascophyllum nodosum) helps normalize thyroid glands function, and hormonal production for normal metabolism, and high energy level. Stable metabolism has a positive effect on the immune system of the body. Supplemental Norwegian kelp intake helps with toxin removal.
Per 1 capsule:
Proprietary Blend - 287.5 mg: Red clover (Trifolium pratense) flower 4:1 extract, Licorice root (Glycyrrhiza glabra), Beet root (Beta vulgaris), Sarsaparilla root (Smilax officinalis), Prickly ash (Zanthoxylum americanum) bark, Norwegian kelp (Ascophyllum nodosum).
Packaging size: 60 capsules.
As a dietary supplement take 1 capsule with a large glass of water daily and gradually increase the usage over a 2-3 week period to 2 capsules 3 times daily. Use for one month.
Researchers found that alginic acid, one of the important intercellular polysaccharides found in large brown algae like Kelp, has detoxifying qualities.
The EPA's Environmental Toxicology Lab found that alginates could bind and eliminate both radionucleides such as Strontium 90 and heavy metals such as cadmium. They also discovered that Strontium already stored in the bones was re-secreted and bound by the alginates and safely passed through the intestines. Thus the remarkable kelps can help alleviate past as well as present toxic contamination. (1)
Following ingestion of fucoidan , CD34(+) cells increased significantly in the PB from 1.64 to 1.84 cells/microL after 4 days. The proportion of CD34(+) cells that expressed CXCR4 increased from 45 to 90% after 12 days, the plasma level of SDF-1 increased from 1978 to 2010 pg/mL, and IFN-gamma level increased from 9.04 to 9.89 pg/mL.
Oral fucoidan significantly amplified the CXCR4(+) HPC population. The ability to mobilize HPC using sulfated polysaccharides and mobilize more HPC with high levels of CXCR4 could be clinically valuable. (2)
Glycyrrhizic acid (GA), the major bioactive triterpene glycoside of glycyrrhiza, has been shown to possess a wide range of pharmacological properties, including anti-inflammatory and anti-viral properties. However, few studies have examined the anti-allergic activity and exact mechanism of action of GA. In the present work, the anti-allergic activity and possible mechanisms of action of GA on an immunoglobulin (Ig) E-mediated allergic reaction has been studied using three models of allergic reaction in vivo and in vitro. Active systemic allergic reaction in Balb/c mice showed that GA could suppress the increased level of IL-4 to restore the immune balance of TH1/TH2 cells in a dose-dependent manner. Additionally, GA attenuated significantly the B cells producing allergen-specific IgE and IgG1 partly because of the low levels of TH2 cytokines. Both passive cutaneous anaphylaxis in vivo and an RBL-2H3 cell-based immunological assay in vitro indicated that GA acted as a "mast cell stabilizer", as it inhibited mast cell degranulation and decreased vascular permeability by inhibiting the expression of Orai1, STIM1 and TRPC1, which blocked extracellular Ca2+ influxes. The current study suggests that GA may serve as an effective anti-allergic agent derived from food for the prevention and treatment of IgE-mediated allergic reaction. (3)
Licorice is a common herb, which has been used, in traditional Chinese medicine for centuries.
Presently we have summarized the antiviral and antimicrobial activities of licorice. Many studies found that several components were responsible for the antiviral and antimicrobial activities through different mechanisms. Licorice contains more than 20 triterpenoids and nearly 300 flavonoids. Among them, only two triterpenes, GL (glycyrrhizin) and GA (18β-glycyrrhetinic acid) have been reported to have antiviral effects. They can weaken virus activities by inhibiting virus gene expression and replication, reducing adhesion force and stress, and reducing HMGB1 binding to DNA. They can also enhance host cell activities by blocking the degradation of IκB, activating T lymphocyte proliferation and suppressing host cell apoptosis.
GL is one of the major compounds isolated from the roots of licorice. In recent years, many studies have confirmed the antiviral activity of GL. Compared with GL, studies of the antiviral activity of GA are limited.
In contrast, flavonoids play an important role in the treatment of bacterial infection by decreasing expression of bacterial genes, inhibiting bacterial growth and reducing the production of bacterial toxin.
Increasing antibiotic resistance has resulted in an urgent need for alternative therapies to treat diseases. In recent years, many studies have shown that licorice extracts have potent effects in inhibiting the activities of Gram-positive bacteria and Gram-negative bacteria, such as Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Bacillus subtilis. (4)
Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic drug for liver disease. This review summarizes the current biological activities of GA and its medical applications in liver diseases. The pharmacological actions of GA include inhibition of hepatic apoptosis and necrosis; anti-inflammatory and immune regulatory actions; antiviral effects; and antitumor effects. (5)
In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to 75 years of age, received isoflavones from Red Clover enriched in either biochanin or formononetin (precursors of genistein and daidzein; 80 mg/d) crossed over randomly with placebo in two 6-week periods. The end points were measured at baseline and after each intervention and included large artery stiffness (systemic arterial compliance and pulse wave velocity), endothelial function in conduit arteries (flow-mediated vasodilation), 24-hour ambulatory blood pressure, and total peripheral resistance. Isoflavone intervention significantly reduced arterial stiffness with improved systemic arterial compliance (P=0.04; repeated-measures ANOVA, Bonferroni correction) attributable to a reduction in total peripheral resistance (P=0.03) and a corresponding reduction in central pulse wave velocity (P=0.02) compared with placebo. Isoflavones did not affect blood pressure (P=0.5) or flow-mediated vasodilation (P=0.44). Improvements seemed limited to formononetin-enriched isoflavones (adjusted P=0.06). Formononetin treatment also reduced circulating vascular adhesion cell molecule-1 (P<0.01).
In normotensive men and postmenopausal women, red clover isoflavones enriched in formononetin reduced arterial stiffness and total vascular resistance but had no effect on blood pressure. These effects may partly explain the lower cardiovascular risk in populations eating isoflavone-rich diets. (6)
Red Clover (Trifolium pratense) has been traditionally used as forage or soil improver, but now it is seen as the plant with vast therapeutic activities shown in various in vivo, in vitro and ex vivo experiments.
Red Clover extract contains high amount of isoflavones daidzein, genistein, formononetin, biochanin A.
A review of biological activities of Trifolium Pratense shows that the active constituents have cardioprotective, antioxidant, neuroprotective, osteoprotective properties, anti-platelet effect, help in the elimination of toxins, have antimicrobial and antifungal properties, and show anti-inflammatory activity. (7)
Red beetroot (Beta vulgaris), as a naturally occurring root vegetable and a rich source of phytochemicals and bioactive compounds. Beetroot consists of multiple biologically active phytochemicals including betalains (e.g., betacyanins and betaxanthins), flavonoids, polyphenols, saponins and inorganic nitrate (NO3); it is also a rich source of diverse minerals such as potassium, sodium, phosphorous, calcium, magnesium, copper, iron, zinc and manganese.
Beetroot is classified as one of the ten plants with the highest antioxidant activity.
Available data supported the health-promotional properties of beetroot and its byproducts, as a potential therapeutic treatment for various metabolic disorders including hypertension, diabetes, insulin resistance and kidney dysfunction. In human studies to date, beetroot supplementation has been reported to reduce systolic and diastolic blood pressure, inhibit platelet aggregation, improve vascular and endothelial function, reduce blood glucose and improve insulin homeostasis, and possess reno-protective properties. (8)
Leaf, fruit, stem, bark and root of Zanthoxylum americanum were investigated for antifungal activity with 11 strains of fungi representing diverse opportunistic and systemic pathogens, including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. All extracts demonstrated a broad spectrum of antifungal activity and inhibited at least eight fungal species in a disk diffusion assay (600 microg/disk). Antifungal activity was light-dependent, with fruit and leaf extracts most active in general. The presence of light-mediated compounds, such as psoralen, 8-methoxypsoralen and imperatorin in extracts of different organs was confirmed by RP-HPLC. A high furanocoumarin content was detected in fruit and leaf and low furanocoumarin levels were found in bark and wood. A high positive correlation was observed between total furanocoumarin content and fungal inhibition zones (r2=0.902, p<0.001). The results provide a phytochemical basis for the very widespread use of Z. americanum in indigenous North American ethnomedical tradition for conditions that may be related to fungal infections. (9)
1. Steven Schacter, Fighting Radiation with Food, Herbs and Vitamins, East West Health Books, 1988
2. Irhimeh MR1, Fitton JH, Lowenthal RM. Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells. Exp Hematol. 2007 Jun;35(6):989-94.
3. Han S1, Sun L2, He F2, Che H3. Anti-allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells. Sci Rep. 2017 Aug 3;7(1):7222.
4. Liqiang Wang, Rui Yang, Bochuan Yuan, Ying Liu, and Chunsheng Liu The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. PMID: 26579460
5. Jian-yuan Li, Hong-yan Cao, Ping Liu, Gen-hong Cheng, and Ming-yu Sun , Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review. Acta Pharm Sin B. 2015 Jul; 5(4): 310–315.
6. Helena J. Teede; Barry P. McGrath; Lakmini DeSilva; Marja Cehun; Andriana Fassoulakis; Paul J. Nestel. A Placebo-Controlled Study in Men and Postmenopausal Women. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23:1066.
7. Atiq-ur-Rehman, Faculty of Pharmacy, The University of Lahore and University College of Pharmacy, University of the Punjab, Lahore Pakistan. Biological Activities of Trifolium Pratense: A Review. Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Published: August 16, 2019
8. Parvin Mirmiran, Zeinab Houshialsadat, [...], and Fereidoun Azizi Functional properties of beetroot (Beta vulgaris) in management of cardio-metabolic diseases. Nutr Metab (Lond). 2020 Jan 7;17:3. doi: 10.1186/s12986-019-0421-0. eCollection 2020.
9. Bafi-Yeboa NF1, Arnason JT, Baker J, Smith ML. Antifungal constituents of northern prickly ash, Zanthoxylum americanum mill. Phytomedicine. 2005 May;12(5):370-7.