Sanoprost™ TR (60)
Sanoprost TR contains standardized extracts of Saw Palmetto, Pygeum and Stinging Nettle. Sanoprost TR is manufactured using the state-of-the-art (Timed Release™ (TR) Technology) that is designed to release nutrients in a controlled pattern promoting prolonged action and optimal assimilation.
The product has been manufactured using high quality pure raw materials and the technology that ensures all their beneficial properties intact, in strict compliance with GMP and TÜV regulations.
This unique product from Santegra® - Sanoprost™ TR is designed to maintain prostate health.
Prostate gland grows larger as men age, a condition known as Benign Prostatic Hyperplasia (BPH). Prostate gland encircles male urethra, and enlargement in prostate gland blocks urinary passage, causing BPH symptoms including difficulty in starting the urine flow, bedtime and frequent urination, decreased urine stream, dribbling after urination ends, the size and strength of the urine stream may decrease. These symptoms can make your life intolerable.
BPH affects some 10 million men in the US each year. At least 50% of men after the age of 50 would develop enlargement of prostate. Almost 90% of men aged 70-80 or older suffer from BPH and many of them resort to surgery. BPH is an age-related non-malignant enlargement of the prostate gland due to increased numbers of cells triggered to grow in the prostate.
This original blend is a combination of three well known herbs from different parts of the world: Saw Palmetto, Pygeum and Stinging Nettle. But this is not the only news. The new coating technology was used to give this product a Timed Release Effect. The combination of this two inventions helps not only in the delivery of the bioactive nutrients, it also controls the release of the ingredients in a programmed, more beneficial manner. For centuries the extracts of these herbs have been used for genitor-urinary complaints, but in the combination with new technology it is going to provide more pronounced results.
Saw Palmetto have been known and used by men for centuries to increase sexual vigor, to improve sperm production, and to prevent hair loss. It has been considered useful as a urinary antiseptic and diuretic, but its most effective use is to relief symptoms of BPH. The extract comes from the berries of the dwarf palm tree Saw palmetto (Serenoa Repens). Saw palmetto contains phytosterols, substances that curb prostate cell growth. Many reports and studies suggest that use of saw palmetto can decrease the size of the prostate and improve urinary symptoms after months of use. Although Saw palmetto does not affect certain hormonal levels, there is clinical evidence, however, to suggest that its mechanism of action is similar to that of the commonly prescribed prostate drugs.
Dosage: Sanoprost™ TR contains 160 mg of Saw Palmetto standardized extract per tablet, with the recommended daily dose of 320 mg (2 tablets per day). Numerous trials proved this amount of extract to be the most effective daily dosage.
While saw palmetto extract is the far better known herbal medication to reduce the size of an enlarged prostate, Pygeum may in many cases be as effective. Pygeum, also known as African plum grows in the high plateaus of South Africa. Pygeum has been approved for treating mild to moderate BPH in Europe since the early 1970s. The bark appears to work by reducing inflammation, promoting urination, and ridding the prostate of cholesterol deposits that can occur with BPH. Symptoms of prostate problems may ease as a result.
Dosage: The most effective dosage of Pygeum bark extract (25 % total sterols) is used in Sanoprost™ TR: 50 mg per tablet and 100 mg (2 tablets) as a recommended daily dosage.
In folk medicine Stinging Nettles have been used as a diuretic, to build up the blood, for arthritis and rheumatism. Many remarkable healing properties are attributed to Stinging Nettle, and the leaf is utilized for different problems than the root. The leaf is traditionally used as a diuretic, for arthritis, prostatitis, rheumatism, rheumatoid arthritis, high blood pressure and allergic rhinitis. The root is recommended as a diuretic, for relief of BPH and other prostate problems.
Dosage: Stinging Nettle content in Sanoprost™ TR is 120 mg of 25:1 extract per capsule or 240 mg daily dose (one tablet twice a day), which is equal to 6 g of raw Stinging Nettle root powder – the amount proved to be effective in various clinical trials.
Timed release effect vs Typical delivery system.
Sanoprost™ TR tablets are produced with the help of new Timed Release Technology.
Patented Timed Release Technology uses a proprietary blend of specially processed natural fibers. When this fiber-nutrient matrix contacts gastric fluids it forms a gel-like mass, which releases the nutrients gradually just like the fiber in whole foods. The gel-like mass creates a drag effect in the GI tract to slow its transit time. This allows the nutrients ample time to be released while still in the small intestine. Standard nutritional tablets and capsules are not specially formulated to release their ingredients in any programmed manner. There is no guarantee where or when the active ingredients will release. Clinically tested Timed Release Technology gives Sanoprost™ TR precise sustained release.
Per one tablet:
Saw palmetto (Serenoa repens) berries extract (8:1) (90% total sterols and free fatty acids) (equivalent to 1280 mg of crude herb) – 160 mg;
Pygeum (Prunus Africana) bark extract (4:1) (25% total sterols) (equivalent to 200 mg of crude herb) - 50 mg; Stinging nettle (Urtica Dioca) root extract (25:1) (equivalent to 3000 mg of crude herb) - 120 mg.
As a dietary supplement take 1 tablet with a large glass of water, 2 times a day.
Saw Palmetto promotes prostate health by decreasing the metabolism and action of male steroids. Saw Palmetto has been demonstrated to decrease the activity of 5-alpha reductase which stimulates the conversion of testosterone to dihydrotestosterone (DHT), its more active form. (6) Since DHT is necessary for excessive growth (hyperplasia) of the prostate and is elevated in men with BPH, inhibition of 5-alpha reductase, and therefore DHT production, may alleviate BPH and associated compression of the urethra (the tube that runs through the prostate gland to carry urine from the bladder). Additionally, studies have shown that Saw Palmetto helps to inhibit the production of various inflammatory factors, thus serving to decrease overall prostate inflammation.
Clinical studies have used a dosage of 160 mg twice daily or 320 mg once daily of a lipophilic extract containing 80 to 90 percent total sterols and free fatty acids. A daily dosage of 480 mg was not found to be any more effective in a six-month study of dosages.
Animal studies indicate that partial outlet obstruction to the bladder may lead to bladder contractile problems. In rabbit study, BPH-like symptoms were prevented by pre-treatment with Pygeum extract. The action of Pygeum may be protecting the bladder against lack of oxygen caused by or as a result of injury.
The accepted form of Pygeum used in Europe for treatment of BPH is a lipophilic extract standardized to 13% total sterols. Men with mild to moderate BPH sometimes take 50-100 mg two times per day. A double-blind trial found that 100 mg once daily was as effective as 50 mg twice per day.
The root of stinging nettle contains scopoletin, sterols, fatty acids, polysaccharides and isolectins. Several of nettle’s lectin chemicals have demonstrated marked antiviral actions. Other chemicals (flavonoids in the leaves and a lectin in the root) have been documented with interesting immune stimulant actions in preliminary research.
The last area of research on nettle focuses on its usefulness for prostate inflammation (prostatitis) and benign prostate hyperplasia (BPH). In more than 20 clinical studies thus far, nettle root (and nettle combined with other herbs) has demonstrated an improvement of clinical symptoms in BPH and prostatitis. While nettle’s benefit for prostatitis is related to its documented anti-inflammatory properties demonstrated in the arthritis and rhinitis research, the effect of nettle on BPH is different—it works on a hormonal level.
Some of the more recent research on BPH and nettles indicates that nettle can interfere with or block a number of hormone-related chemical processes in the body that are implicated in the development of BPH. In clinical research, nettles have demonstrated the ability to stop the conversion of testosterone to dihydrotestosterone (by inhibiting an enzyme required for the conversion).
It all sounds a bit complicated, but basically, most all of the complex intercellular processes required to trigger the prostate to grow new cells and enlarge seem to be inhibited by nettle.
This is great news for men suffering from BPH (and there are millions)! Human and animal studies have confirmed these effects and benefits.
In the large study, European researchers gave either saw palmetto or the prescription drug Proscar to more than 1,000 men for six months. Both proved equally effective in relieving — but not eliminating — the symptoms of BPH. (1)
The clinical effectiveness of saw palmetto has been shown in trials lasting from six months to three years. A three-year trial in Germany found that taking 160 mg of Saw Palmetto extract twice daily reduced nighttime urination in 73% of patients and improved urinary flow rates significantly. (2)
In another 12-weeks study on 1334 patients taking saw palmetto extract, 80% of the patients reported the results as good or excellent.
One more trial with 40 men suffering from BPH, during the course of the trial they took saw palmetto extract for 60 days and demonstrated the following results: 25% reported good results, but 75% reported excellent results and decrease in BPH symptoms.
Many other studies showed the major improvement in urinary flow, and the quality of life.
The clinical trial was conducted in Europe on 85 men between the age of 50 and 75, with mild BPH symptoms. After 2 months of treatment with pygeum extract the following results were reported: 32% of participants confirmed the decrease in nocturnal urination frequency, 31% - the improvement in the quality of life. Overall before the treatment with pygeum2/3 of men experienced the need for 3 or more urinations during the night. After the treatment the need for bedtime urination came down to 1, and in some cases disappeared completely. These improvements continued even after the treatment with pygeum had been stopped. Some patients admitted the increase in sexual activity. (3)
Many clinical trials on animals, as well as humans, proved the effectiveness of stinging nettles. For example it was demonstrated during one of the studies that stinging nettles root extract slowed down the prostate cell growth by 30% within 5 days; another study (on mice) showed 51.4% decrease in prostatic hyperplasia.
The 134 patients (aged 53 to 84 years) with symptoms of benign prostatic hyperplasia were drawn from two medical centers in Warsaw. The patients received 300 mg of stinging nettle root extract combined with 25 mg of pygeum africanum bark extract. After 28 days treatment, urine flow, residual urine, and nocturia were significantly reduced. (4)
One more double study was conducted on 543 patients, they were treated with the combination of stinging nettle root extract and saw palmetto extract. As a result the average urine volume during urination increased, the frequency decreased, and other BPH symptoms also decreased. It demonstrated that the combination of stinging nettle root extract and saw palmetto extract is effective in reducing BPH symptoms. (5)
1. Prostate 29: 231-240 (1996)
2. Bach D, Ebeling L. Long-term drug treatment of benign prostatic hyperplasia-results of a prospective 3-year multicenter study using Sabal extract IDS 89. Phytomedicine 1996;3:105-11.
3. Breza J, Dzurny O, Borowka A, et al. Efficacy and acceptability of Tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): a multicentre trial in central Europe. Curr Med Res Opin 1998;14:127-139.
4. Clin Ther. 1993 Nov-Dec; 15(6):1011-20.
5. BJU Int. 2000 Sep; 86(4):439-42.
6. Di Silverio F, Monti S, Sciarra A, et al. Effects of long-term treatment with Serenoa repens (Permixon®) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. Prostate 1998;37:77-83.