Passion Flower GP (30)

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Passion flower GP is a natural non addictive calming remedy, contains standardized 4:1 passion flower extract (aerial parts) (3.5% vitexin)(equivalent to 1200 mg of crude herb) to guarantee its potency and consistency.

The product has been manufactured using high quality pure herbs and the technology that ensures all their beneficial properties intact, in strict compliance with GMP and TÜV regulations.

Today, passion flower is official in the national pharmacopeias of Egypt, France, Germany, and Switzerland, and also monographed in the British Herbal Pharmacopoeia and the British Herbal Compendium, the ESCOP monographs, the Commission E, the German Standard Licenses, the German Homeopathic Pharmacopoeia, and the Homeopathic Pharmacopoeia of the United States.
The British Herbal Compendium indicates its use for sleep disorders, restlessness, nervous stress, and anxiety. Other uses include neuralgia and nervous tachycardia (Bradley, 1992). The German Standard License for passionflower tea indicates its use for nervous restlessness, mild disorders of sleeplessness, and gastrointestinal disorders of nervous origin (Bradley, 1992; Wichtl and Bisset, 1994). ESCOP indicates its use for tenseness, restlessness, and irritability with difficulty in falling asleep (ESCOP, 1997).

Key constituents in passion flower include flavonoids (vitexine, kamferol, quercetin, rutin), harman indole alkaloids, maltol, cyanogenic glycosides, phytosterol and etc.

Passion Flower GP contains standardized passion flower (Passiflora incarnata) 4:1 extract (aerial parts) (3.5% vitexin) to guarantee its effectiveness.

Passion flower helps to relax, effective for increased arterial pressure caused by nervous tension; tachycardia; helps with spasms, hysteria and the raised irritability. (3,4)

Passion flower is applied as a sedative for a neurasthenia, dystonia, disturbing conditions, and overexcitation.
Besides it is revealed, that passion flower’s active ingredients influence serotonin level, promoting mood improvement.

Passion flower renders positive influence on nervous system, especially during hormonal changes. It is recommended for perimenopausal and menopausal complaints. (5)

Passion flower is useful for cough. The decrease in frequency of bronchial asthma attacks was noted with regular intake of passion flower.

Passion Flower GP is fine sleeping aid. The product is safe and does not cause dependency.

Passion Flower GP is recommended to use in antialcoholic program.

Per one capsule:

standardized Passion flower (Passiflora incarnata) 4:1 extract (aerial parts) (3.5% vitexin)(equivalent to 1200 mg of crude herb) - 300 mg.


Packaging size: 30 capsules.



As a dietary supplement take 1-2 capsules with a large glass of water with meals for one month.



Individual intolerance, asthenia. 
If you are pregnant, consult your physician prior to taking this product.
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Passion flower is one of the most popular natural relaxants.
Main passion flower active ingredients are: flavonoids (vitexine, kamferol, quercetin, rutin), alkaloid (harman, maltol, phytosterol, and etc.)
Pharmacological effect of passion flower is caused, basically, by flavonoid and alkaloid activity.

Flavonoids render spasmolytic, hypotensive, cardio and capillary toning, coronary vasodilating, antiarrhythmic, anti-oxidant action. (11)
Maltol possesses calming property.
Alkaloids demonstrate antispasmodic effect on smooth muscles, promote blood vessels dilatation, and decrease arterial pressure.
It is sugested that alkaloids (harman) are capable to inhibit monoamine oxidase enzyme, related to depression. This enzyme destroys neurotransmitters in the brain, especially dopamine, norepinephrine and serotonin that influence mood stability. By inhibiting monoamine oxidase, neurotransmitters’ level raises, improving mood.

Though the mechanism of passion flower action is not completely studied, it is considered that active substances of this plant are raising neurotransmitter level in the brain - Gamma-aminobutyric acid (GABA). Gamma-aminobutyric acid reduces brain cells activity, causing relaxation, reducing nervousness and promots falling asleep.

European Herbal Pharmacopoeias recommend passion flower extract containing no less than 0.8% total flavonoids.
Passion Flower GP by Santegra® contains the standardized extract (4:1) of aerial parts with 3.5% vitexin flavonoid.

Human studies of Passiflora species as a sedative/anxiolytic have been conducted. In a multicenter, double-blind trial of 91 patients, Passiflora exhibited statistically significant differences when compared with placebo in the treatment of adjustment disorder with anxious mood. (6)

“A double-blind randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the treatment of generalized anxiety disorder (GAD). The study was performed on 36 out-patients diagnosed with GAD. Patients were allocated in a random fashion: 18 to the Passiflora extract 45 drops/day, and 18 to oxazepam 30 mg/day plus placebo drops for a 4-week trial. RESULTS: Passiflora extract and oxazepam were effective in the treatment of generalized anxiety disorder. No significant difference was observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of action. On the other hand, significantly more problems relating to impairment of job performance were encountered with subjects on oxazepam.
The results suggest that Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the low incidence of impairment of job performance with Passiflora extract compared to oxazepam is an advantage." (7)

A number of Indian studies have shown a clear anxiolytic (anti-anxiety) activity of Passiflora incarnata in both animals and humans.
Since ancient time passion flower is used for treatment of nervousness and sleeplessness, scientists have made an attempt to establish with the help of chromatography, which active substances of Passion flower are responsible for this positive influence.
Sedative effect was observed in mice with an artificially produced anxiety with the use of 10 mg/kg methanol Passiflora extract. Active components have been presented in the form of blue and turquoise fluorescing spots in ultra-violet light range of 366 nm. It is supposed, that bioactivity of passion flower is caused by phytocomponents with benzo flavonoid nucleus. (8)

The results of a double-blind randomized controlled trial of clonidine plus passiflora extract vs. clonidine plus placebo in the outpatient detoxification of 65 opiates addicts suggested that passiflora extract may be an effective adjuvant agent in the management of opiate withdrawal. A total of 65 opiates addicts were assigned randomly to treatment with passiflora extract plus clonidine tablet or clonidine tablet plus placebo drop during a 14-day double-blind clinical trial. All patients met the DSM IV criteria for opioid dependence. The fixed daily dose was 60 drops of passiflora extract and a maximum daily dose of 0.8 mg of clonidine administered in three divided doses. The severity of the opiate withdrawal syndrome was measured on days 0, 1, 2, 3, 4, 7 and 14 using the Short Opiate Withdrawal Scale (SOWS).
Both protocols were equally effective in treating the physical symptoms of withdrawal syndromes. However, the passiflora plus clonidine group showed a significant superiority over clonidine alone in the management of mental symptoms.  (9)

The passion flower extract demonstrates sedative effect and can be used as a sedation before surgeries that has been shown in one of experiments. (10)

1. Foster S. Herbs for Your Health. Loveland, CO: Interweave Press, 1996, 68-9.

2. Lutomski J, Segiet E, Szpunar K, Grisse K. The importance of the passionflower in medicine [in German]. Pharm Unserer Zeit . 1981;10:45-49.

3. Chevallier A. Encyclopedia of Medicinal Plants . New York, NY: DK Publishing; 1996;117.

4. Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants . Paris, France: Lavoisier Publishing Inc.; 1995:284-285.

5. Israel D, Youngkin EQ. Herbal therapies for perimenopausal and menopausal complaints. Pharmacotherapy . 1997;17:970-984.

6. Bourin M, Bougerol T, Guitton B, Broutin E. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study vs placebo. Fundam Clin Pharmacol . 1997;11:127-132.

7. Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001 Oct;26(5):363-7

8. Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. J Ethnopharmacol. 2001 Dec;78(2-3):165-70

9. Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clin Pharm Ther. 2001 Oct;26(5):369-73

10. Yaniv R, Segal E, Trau H, Auslander S, Perel A. Natural premedication for mast cell proliferative disorders. J Ethnopharmacol. 1995;46:71-72.

11. Meier B. Passiflora incarnata L.-Passion flower: Portrait of a medicinal plant. Zeitschrift Phytother 1995;16:115-26.