Use carefully if you have reduced blood clotting.
The combination of the unique old recipes with the latest achievements of nutritional science. Gotu Kola GP contains Gotu kola leaf extract (12:1) standardized to 10% asiaticoside (equivalent to 1800 mg of crude herb) to guarantee its efficacy.
This product has been manufactured using high quality pure herbs and the technology that ensures all their beneficial properties intact, in strict compliance with GMP and TÜV regulations.
Originally an Asian medicine, Gotu kola (Centella asiatica) has been used for centuries for many conditions, including asthma, bronchitis, heart problems, nervous disorders, dysentery, epilepsy, insomnia, jaundice, eye conditions, exhaustion, inflammation, high blood pressure, diarrhea, and problems with urination.
In Sri Lanka, it was used to prolong life; in China it is called "miracle elixirs of life".
Perhaps the best known benefit of Gotu kola is its ability to improve symptoms of varicose veins. Gotu kola helps in strengthening the capillaries and veins and assists with better blood circulation.
Clinical trials have confirmed its ability to relieve symptoms of poor circulation in the veins of the legs. The herb has been used successfully to reduce symptoms of varicose veins, as well as leg cramps, swelling of the legs, and "heaviness" or tingling in the legs.
It has also shown, in a number of recent tests, a notable ability to speed the healing of wounds and burns.
Gotu kola also has a historical reputation for boosting mental activity; it is called "food for the brain".
This oriental herb has demonstrated mild tranquilizing, anti-anxiety and anti-stress effects, as well as improving mental functions such as concentration and memory.
It has a calming effect on the body and is used to support the central nervous system.
Gotu kola supports circulatory system: improves brain and peripheral circulation, helps to lower intracranial pressure, and normalize high blood pressure. It also has mild diuretic properties.
Gotu kola is an ideal tonic for the elderly people, who are more likely to have problems with weakened blood vessels, particularly their veins. Also, it may take longer for their skin to heal after cuts, scratches, bruises, or similar injuries. Gotu kola helps with both of these problems – plus, it helps to improve mental clarity.
Nowadays the unique properties of Gotu kola make it one of the most popular herbs all over the world. The advantage of the new Santegra®’s product Gotu Kola GP is that it contains Gotu kola leaf extract (12:1) standardized to 10% asiaticoside to guarantee its efficacy.
Per 1 capsule:
standardized Gotu kola (Centella asiatica) leaf 12:1 extract (10% asiaticosides – 15 mg) (equivalent to 1800 mg of crude herb) - 150 mg.
As a dietary supplement take 1-2 capsules with a large glass of water daily.
Gotu kola is a perennial plant native to India, Japan, China, Indonesia, South Africa, Sri Lanka, and the South Pacific. It is tasteless and odorless and thrives in and around water. It has small fan-shaped green leaves with white or light purple-to-pink flowers, and it bears small oval fruit. The leaves and stems of the Gotu kola plant are used for medicinal purposes.
The active compounds of Gotu kola were first isolated in the early 1940's. (1)
Gotu kola contains a variety of biologically active chemical groups; it contains triterpenoid glycosides (saponines) , phytosterols and a volatile oil consisting of vallerin, camphor, cineole. Vitamins B and C, Е, К, tannins, several aminoacids, Ca, Mg and Na1.
The triterpenoid glycosides include asiaticoside, asiatoside, asiatic acid, madecassic acid, madicassoside, oxyasiaticoside, brahminoside, brahmoside, centelloside
The active ingredients of Gotu kola were determined to be triterpenoids.
Gotu Kola GP contains standardized Gotu kola (Centella asiatica) leaf 12:1 extract (10% asiaticosides).
Triterpenoids appear to have antioxidant benefits and an ability to stimulate collagen and glycosaminoglycan synthesis for tissue regeneration.
Flavonoids help to improve blood flow, has antispasmodic action on the blood vessels, strengthen the vascular walls, and help to lower intracranial pressure.
Madecassosides has strong anti-inflammatory properties.
Due mostly to the actions of chemicals known as asiaticosides and madecassosides, Gotu kola may prevent, delay, and treat a condition known as chronic venous insufficiency. Asiaticosides and madecassosides help support veins and other blood vessels. Gotu kola strengthens the collagen lining of vein walls, enhances circulation, and reduces inflammation in varicose veins. It may also help to relieve hemorrhoids.
Brahminosides and brahmosides has mild diuretic and calming properties.
In recent animal studies, oral Gotu kola has been shown to have anticonvulsant, pain-relieving, and sedative effects. All of these central nervous system effects are thought to be related to increased levels of gamma aminobutyric acid (GABA) that are associated with taking Gotu kola. GABA is a neurotransmitter (a chemical that carries messages from nerve cells to other cells) that helps to regulate the speed of nerve cell firing. GABA is also known to help prevent seizures and promote relaxation.
Gotu kola helps stimulate nervous system, restore energy. Triterpenoids take part in transmission of nerve signals in the brain, thus improving the function of the central nervous system. Nervous system is supported also due to the high content of vitamin B in this plant, which also helps to transform food into energy.
Gotu kola gently stimulates nervous system. It makes you feel more alert, but without over-stimulating as caffeine does, meaning that you aren't left feeling jittery and anxious.
The herb has also been shown to alleviate stress, anxiety, mental fatigue, and memory problems. (2)
It helps to stimulate brain cell metabolism and protects your cells against possible damage from toxins. (3)
Asiaticoside derived from the plant Centella asiatica is known to possess good wound healing activity. Enhanced healing activity has been attributed to increased collagen formation and angiogenesis. Since antioxidants have been reported to play a significant role in the wound healing process we studied the effect of asiaticoside on the levels of certain antioxidants in the wound so as to explore the possible involvement of such a mechanism in the asiaticoside induced wound healing. Asiaticoside application (0.2%, topical) twice daily for 7 days to excision-type cutaneous wounds in rats led to increased enzymatic and non-enzymatic antioxidants, namely superoxide dismutase (35%), catalase (67%), glutathione peroxidase (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues. It also resulted in a several fold decrease in lipid peroxide levels (69%) as measured in terms of thiobarbituric acid reactive substance. However, continued application for 14 days showed no significant difference in these antioxidants compared with their values in vehicle treated wound tissue. It appears from the present study that asiaticosides enhanced induction of antioxidant levels at an initial stage of healing which may be an important contributory factor in the healing properties of this substance. (4)
The object of this study was to evaluate the healing activity of CothylineTM, a new formulation comprising asiaticosideas the main ingredient in combination with antiseptic adjuvants. The study has two parts: (1) a clinical phase involving the observation of patients afflicted with soiled
wounds and chronic or recurrent atony which was resistant to the usual treatment, and (2) an experimental phase in which the healing action of Cothyline™ was evaluated by light and electron microscopic observation of the morphological changes that occurred in scarified guinea pig skin. Treatment of patients with Cothyline™ completely healed (64%) or improved (16%) the lesions under study. In the animal study, it was shown that changes occurred in the shape and size of the keratohyaline granules, a phenomenon observed during accelerated healing. (5)
Madecassol is an extract of Centella asiatica, a member of the Umbelliferae family. It contains madecassic acid, asiatic acid and asiaticoside. It has been used as a wound healing agent and for the prevention of cicatrization.
Madecassol has also been shown to have a preventive effect on burn and postoperative hypertrophic scars. It compares favorably in effectiveness with compression bandaging, and gives more lasting results than intralesional cortisone or radiation therapy. (6)
Ninety-four patients suffering from venous insufficiency of the lower limbs participated in a multicenter, double-blind versus placebo study. After randomization, they were allotted for a treatment period of two months to one of three groups: Titrated extract of Centella asiatica (TECA) 120 mg/day, TECA 60 mg/day, or placebo. A significant difference (p less than 0.05) in favor of TECA was shown for the symptoms of heaviness in the lower limbs and edema, as well as for the overall evaluation by the patient. The venous distensibility measured by a mercury strain gauge plethysmograph at three occlusion pressures was improved for the TECA groups but aggravated for the placebo group. The results showed a significant dose-related improvement in the treated groups. (7)
Preliminary studies showed Gotu kola ability to boost memory, overcome stress and tiredness.
Gotu kola has been used in traditional Ayurvedic medicine to treat anxiety.
In one clinical trial, scientists gave 40 healthy adults either a very high onetime dose of 12 g of Gotu kola or a placebo. Then they measured the subject’s startle responses with loud bursts of noise. After 60 minutes, the Gotu kola group displayed less than half the startle response of the control group. (8)
Two Indian studies reported that Gotu kola helped improve intelligence, general mental abilities, and behavior in mentally retarded children.
Interesting results were shown in animal study. Rats that ate Gotu kola every day for 14 days had three to 60 times better retention of learned behaviors than rats that took a placebo.
1. J. E. Bontems, Bull. Sci. Pharmacol., (1941) 49,186-96).
2. J Clin Psychopharmacol 2000, 20(6):680-684; J Neurosci Res 1999, 58(3): 417-425).
3. J Ethnopharmacol 2002, 79(2): 253-260).
4. Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res. 1999 Feb;13(1):50-4.
5. Morisset R, Cote NG, Panisset JC, et al. Evaluation of the healing activity of hydrocotyle tincture in the treatment of wounds. Phytother Res 1987;1:117-21.
6. Bossé JP, Papillon J, Frenette G, et al. Clinical study of a new antikeloid drug. Ann Plastic Surg 1979;3:13-21.
7. Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology 1986;37:420-1
8. Bradwejn J, Zhou Y, Koszycki D, et al. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol. 2000;20:680–684.