Carbonyl iron in BoostIron™ has a lot of unique benefits in comparison to other forms of iron: it is NON-TOXIC, contains 98% pure iron and much less likely to cause constipation and diarrhoea. This product has been manufactured using high quality raw materials in a strict compliance with GMP and TÜV regulations.
Iron plays special role in the maintenance of human health. Iron armors protected knights from the fatal wounds in ancient times, but even nowadays the iron shield is vital for everyone. The average amount of iron in the human body is about 4-5 mg, which is essential for the blood production, for the support of the immune system, and is important for the overall health. Iron is an essential component of the hemoglobin molecule: without iron the bone marrow is unable to produce hemoglobin.
Iron deficiency is the most common known form of nutritional deficiency.(1) About 30% of world’s population have iron deficiency anemia.(2) Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues.
First of all the hemoglobin (the oxygen carrying pigment in the blood) synthesis is impaired. As the result the organs and tissues get less oxygen, which can lead to hypoxia, which negatively affects the functin of many organs and reduses the quality of life. All the symptoms of anemia are developing gradually and are not typical, and thus can be very dangerous. Many people who have iron-deficiency anemia don’t realize it.
The most common symptoms are feeling tired and weak, paleness of skin, shortness of breath, dizziness, abdominal pain and lack of appetite. Other symptoms may include headache, feeling irritable. The skin is dry, nails break easily, and there are problems with hair – hair split and fall out. Changes of sense of smell and taste may be other signs of iron-deficiency anemia.
Iron deficiency forces cells to preserve what little iron they have and to maintain essential functions by dramatically reducing the activity of more than 80 different genes. Some of the genes affected by iron deficiency are known to play important roles in generating energy, control aging, protecting the cells from free radicals and copying the cell's genetic code.
Iron deficiency is known to diminish various aspects of immune function. Cell-mediated immune response may be impaired when iron deficiency negatively impacts the iron-requiring enzyme called ribonculeotide reductase, an enzyme that appears to be essential for the proper function of the T-lymphocyte arm of immunity. Adequate levels help maintain cellular immunity and help to protect against some infections.
Some researches suppose that children and teenagers with iron deficiency can have learning difficulties, because iron takes part in the synthesis of neuromediator, particularly dopamine. The hemoglobin level is decreasing gradually, that is why many people get used to the condition. Even if the hemoglobin level is very low, rapid fatigability is often explained by stress and overwork, which are typical for modern lifestyle.
If you noticed some of above-listed symptoms, please contact your doctor! It maybe the sign of iron deficiency and early diagnosis will help you recover faster.
Who is most likely to develop iron deficiency anemia?
The main causes of iron deficiency are: poor absorption of iron by the body, inadequate daily intake of iron, or blood loss. (3)
High-risk groups include: women of child-bearing age who have blood loss through menstruation, especially young women who deprive themselves of food in order to lose weight; pregnant or lactating women who have an increased requirement for iron; infants, children, and adolescents in rapid growth phases. Risk factors are related to blood loss and some conditions, such as peptic ulcer disease. Iron’s absorption is also impaired if the gastric juices acidity is low. Any abnormalities in the gastrointestinal (GI) tract could alter iron absorption and result in iron-deficiency anemia.
Vegetarians are at risk of developing anemia. (4) This usually occurs because they don't eat meat, (especially red meat) which is high in iron. Infants living in inner city areas may be at increased risk of iron-deficiency anemia (5) and suffer more often from developmental delays as a result. (6,7) Supplementation of infant formula with iron up to 18 months of age in inner city infants has been shown to prevent iron-deficiency anemia and to reduce the decline in mental development seen in such infants. (8)
Santegra®’s product – BoostIron™ is developed to prevent iron deficiency anemia. It contains 10 mg of carbonyl iron, vitamin C, folate, vitamin B12, which are essential for the better absorption.
Carbonyl iron has a lot of benefits in comparison with other forms of iron:
• Contains 98% pure iron;
• Does not contain iron salts;
• Carbonyl iron is less likely to cause constipation and diarrhea - a significant problem with iron salt supplements;
• Carbonyl iron is a form of iron easily absorbed by the body.
Vitamin C is a powerful antioxidant, prevents free radical damage, supports the immune system and increases body’s defense against infections.
Folic acid is important for the blood production (essential in red blood cell formation), enhances the absorption of vitamin B 12.
Vitamin B 12 is highly biologically active vitamin, aids in forming red blood cells, supports the immune system. Vitamin B12 also helps in the functioning of the nervous system and together with vitamin C and folic acid takes part in metabolizing protein and fat in the body.
Vitamin C is a powerful antioxidant, prevents free radical damage
Folic acid is important for the blood production
Vitamin B 12 is highly biologically active vitamin
Per 1 table:
- iron (as carbonyl iron) - 10 mg,
- vitamin C (as ascorbic acid) – 70 mg,
- folate (as folic acid) – 200 mcg,
- vitamin B12 (as cyanocobalamin) – 3 mcg.
Iron is essential for oxygen transport in the blood. Iron is the central atom of the heme group, a metal complex that binds molecular oxygen in the lungs and carries it to all of the other cells in the body (e.g., the muscles) that need oxygen to perform their activities.
What is the physiological function of iron in the body?
In the stomach iron molecules are transformed from ferric iron into easy absorbable ferrous iron, which is later absorbed in the upper part of intestine. If the blood has too little iron the absorption increases, if iron is in abundance, the absorption decreases.
Transferrin, the principal iron transporter in the blood and other body fluids, distributes iron throughout the body, principally to the red blood cell precursors in the bone marrow for hemoglobin synthesis. Although the body can store some iron, if the need for iron is higher than the reserve, the level of hemoglobin drops and the iron deficiency is developing.
Women usually lose about 2-3 mg of iron, men about 1-2 a day in feces and sweat. If, for some reason, the iron loss exceeds the intake, the iron stores can be depleted and an absolute iron deficiency develops.
There is a high-risk group, which needs to check their hemoglobin level regularly: pregnant or lactating women who have an increased requirement for iron; infants, children, and adolescents in rapid growth phases; women of child-bearing age who have blood loss through menstruation; persons, who have lost a lot of blood in accidents or during operations.
In a trial of carbonyl iron supplementation for blood donors with a randomized, double-blind design, women 18-40 years of age were given placebo or low-dose carbonyl iron, 100 mg for 56 days after blood donation. Side effects with placebo and carbonyl iron were almost indistinguishable; capsule counts indicated that compliance with both regimens was similar. On the average, more iron was absorbed by donors who initially had no iron reserves (serum ferritin < 12 µg/L) than by those with some stores. Overall, enough iron was absorbed to replace that lost at donation in 85% of the carbonyl iron group but in only 29% of the placebo group (p < 0.001). (9)
Research has shown iron deficiency to be associated with impaired brain function, and iron deficiency in children can result in impaired learning ability and behavioral problems. Supplementation of iron has been shown to prevent iron-deficiency anemia and to reduce the decline in mental development.
Some researchers have reported that up to 25% of adolescent girls in the United States are iron deficient. In one study, the effects of iron supplements were tested in adolescent girls with non-anemia iron deficiency to see if they might improve cognition. This was a double-blind, placebo-controlled trial. Subjects were randomized to receive iron supplements or placebo for eight weeks. Those with iron supplementation were reported to perform significantly better than those in the placebo group on tests related to verbal learning and memory.
Claims that iron boosts energy and enhances exercise performance may be true – provided the claim is limited to those who are iron deficient. Muscle weakness and decreased exercise tolerance can occur in those who are iron deficient but not necessarily suffering from iron-deficiency anemia. Iron deficiency without anemia is not uncommon among some endurance athletes (e.g., long-distance runners), more among women than men.
1. CDC Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm Rep 1998;47:1-29.
2. Stoltzfus RJ. Defining iron-deficiency anemia in public health terms: reexamining the nature and magnitude of the public health problem. J Nutr 2001;131:565S-7S.
3. Hallberg L. Prevention of iron deficiency. Baillieres Clin Haematol 1994;7:805-14.
4. Pollitt E. Poverty and child development: relevance of research in developing countries to the United States. Child Dev 1994;65(2 Spec No):283-95.
5. Hurtado EK, Claussen AH, Scott KG. Early childhood anemia and mild or moderate mental retardation. Am J Clin Nutr 1999;69:115-9.
6. Roncagliolo M, Garrido M, Walter T, et al. Evidence of altered central nervous system development in infants with iron deficiency anemia at 6 mo: delayed maturation of auditory brainstem responses. Am J Clin Nutr 1998;68:683-90.
7. Williams J, Wolff A, Daly A, et al. Iron supplemented formula milk related to reduction in psychomotor decline in infants from inner city areas: randomised study. BMJ 1999;318:693
8. Dallman PR. Iron deficiency and the immune response. Am J Clin Nutr. 1987; 46:329-334.
9. Gordeuk VR, Brittenham GM, Bravo J, Hughes MA, Keating LJ. Department of Medicine, Cleveland Metropolitan General Hospital, Ohio.